Transforming complex healthcare environments involves more than just aesthetics; it requires a deep understanding of the people who provide and receive care. Gresham Smith lead a comprehensive redesign of a Florida Oncology outpatient and infusion center. Frontline staff, leadership, and designers collaborated in Design Thinking workshops to reimagine an ideal care-day experience that meets organizational goals while prioritizing patients, families, and staff. The goals of these workshops was to foster a client-centered experience, establish a collaborative and transparent partnership, and confirm client goals to optimize results. Clinician-led journey mapping identified pain points such as confusing wayfinding, overcrowded areas, outdated spaces, limited privacy, and workflow inefficiencies, which directly informed design goals that the Gresham Smith team then aligned with FGI requirements for circulation and signage, patient privacy, and functional adjacencies for treatment spaces. The resulting redesign introduced dedicated procedure and triage zones, enhanced privacy partitions (e.g., solid doors or vision panels to ensure visual privacy), created consistent wayfinding strategies, and healing environments enriched with biophilic design elements—all in accordance with FGI guidance on infection control, accessibility, and stress mitigating environments. Staff well-being was supported through a thoughtfully placed break area to optimize circulation and efficiency, featuring access to natural light, ergonomic furnishings, and alignment with FGI guidelines for staff support and stress reduction. This clinician-driven, guideline-aligned approach effectively addressed real-world challenges, leading to measurable improvements in care quality, patient experience, and staff satisfaction. By sharing this process and its results, the session shows how evidence-based design, based on the FGI requirements, can create healthcare spaces that support efficient workflows, align clinical and organizational priorities, and promote well-being for all users.